陈林，博士，副教授，化学系，毕业于吉林大学。

工作内容：教学科研

通讯地址：齐齐哈尔市文化大街42号化学与化学工程学院化工楼304室

电子邮件：chenlin201308@163.com

研究领域：计算生物学；计算机辅助药物设计；环境计算毒理学

招生学科：能源化学，学科教学（化学）

教育及科研经历：

2004-2008年 周口师范学院化学化工学院 本科

2008-2010年 吉林大学化学学院 硕士

2010-2013年 吉林大学化学学院 博士

2016年至今  齐齐哈尔大学化工学院 副教授 硕士生导师

荣誉和奖励

黑龙江省科学技术奖(自然科学类)三等奖一项（2016），黑龙江省高层次人才E类（2025年），齐齐哈尔大学毕业设计（论文）优秀指导教师。.

科研论文

1. H.Q. Zhang, L. Chen, and R.G. Wang, Dual MDM2 and PPARG regulatory axes mediate the antiepileptic effects of Gouteng: An integration of bioinformatics, network pharmacology, machine learning, molecular docking, and MD simulations. Neuropharmacology, 2026, 300, 111140.

2. Y.H. Zhao, L. Chen, R.G. Wang, Decoding the impact of Surfactants on the interaction between Lipase TpS9 and pNPP through Molecular Docking and MD Simulations. Journal of Environmental Chemical Engineering, 2026, 14(2), 122100.

3. R.G. Wang, Q.X. Bai, L. Chen. Study on the Binding Selectivity of Three Pyridinone Analogs With BRD4 Using Multiple Molecular Dynamics Simulations. Advanced Theory and Simulations, 2026, 9(3), e01827.

4. S. Jiang, L. Sang, Y. Zhao, R.G. Wang, L. Chen. Insight Into Selective Binding Mechanism of BRD4 to Inhibitors 21r, Lpd22, and XY221 Through Molecular Docking and MD Simulations. International Journal of Quantum Chemistry, 2026, 126(3), e70146.

5. J.W. Yang, L. Chen, B. Zhao, R.G. Wang, Molecular docking and molecular dynamics simulations revealed interaction mechanism of acetylcholinesterase with organophosphorus pesticides and their alternatives. Archives of Toxicology, 2025, 99(6), 2433-2446.

6. Y.H. Zhao, L. Chen, B. Zhao, R.G. Wang, Deciphering surfactants modulation of PersiLipase1-p-NPL interaction via MD simulations. Journal of Environmental Chemical Engineering, 2025, 13(5), 117839.

7. S. Wang, R.G. Wang, J.W. Yang, L. Xu, B. Zhao, L. Chen, Molecular mechanism of interactions of SPIN1 with novel inhibitors through molecular docking and molecular dynamics simulations. SAR QSAR Environ. Res. 2025, 36(1), 57-77.

8. Q.X. Bai, R.G. Wang, S.L. Qin, B. Zhao, L. Chen, Binding Selectivity of Inhibitors to BRD2 Uncovered by Molecular Docking and Molecular Dynamics Simulations. Adv. Theor. Simul. 2025, 2401262.

9. W. Chen, L Sang, R.G. Wang, D.H. Zou, L. Chen, Selective inhibition mechanism of three inhibitors to BRD4 uncovered by molecular docking and molecular dynamics simulations. SAR QSAR Environ. 2024, 35(12), 1199-1219.

10. X.N. Yao, L. Chen, B. Zhao, R.G. Wang, Theoretical study on the influence of three different surfactants on the binding of laccase with bisphenol A, J. Mol. Liq. 2024, 403, 124848.

11. R.G. Wang, Y.Q. Lin, B. Zhao, L. Chen, Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations, Environ. Int. 2024, 190, 108926.

12. R.G. Wang, L.X. Duan, B. Zhao, L. Chen, Molecular recognition between volatile molecules and odorant binding proteins 7 by homology modeling, molecular docking and molecular dynamics simulation, J. Sci. Food Agr. 2024, 104(12), 7592-7602.

13. F. Bu, L. Chen, Y. Sun, B. Zhao, R.G. Wang, Insight into the Binding Interaction between PEDCs and hERRγ Utilizing Molecular Docking and Molecular Dynamics Simulations, Molecules, 2024, 29(14), 3256.

14. J.W. Yang, L. Chen, X. Huang, B. Zhao, R.G, Wang. Binding interactions of EDCs to human estrogen-related receptor gamma deciphered by multiple molecular dynamics and energy calculations, Int. J. Quantum Chem. 2024, 124(1), e27333.

15. L. Chen, X. Huang, Y. Li, B. Zhao, M. Liang, R. Wang, Structural and energetic basis of interaction between human estrogen-related receptor γ and environmental endocrine disruptors from multiple molecular dynamics simulations and free energy predictions, J. Hazard. Mater. 2023,443, 130174.

16. Y.F. Li, L. Chen, Y. Sun, R.G. Wang, B. Zhao, T. Jing, Exploring the effect of surfactants on the interaction between laccase and bisphenol A by molecular docking, molecular dynamics, and energy calculations, J. Mol. Liq. 2023, 382, 121928.

17. Y.F. Li, L. Chen, J. Li, B. Zhao, T. Jing, R.G. Wang, Computational explorations of the interaction between laccase and bisphenol A: influence of surfactant and different organic solvents, SAR QSAR Environ. Res. 2023, 34(12), 963-981.

18. C. Wang, L. Chen, W.X. Tang, B. Zhao, R.G. Wang, Molecular basis of RNA recognition by TBP of HIV‐1 from multiple molecular dynamics simulations and energy predictions, J. Comput. Chem. 2023, 44(13), 1291-1299.

19. R.G. Wang, H. Sun, W. Chen, B. Zhao, L. Chen, Molecular basis of ssDNA recognition by RBM45 protein of neurodegenerative disease from multiple molecular dynamics simulations and energy predictions, J. Mol. Graph. Model. 2023, 118, 108377.

20. Y.F. Li, L. Chen, Z.S. Han, R.G. Wang, T. Jing, B. Zhao, Exploring the effects of mutations on NFAT5‐DNA binding using molecular dynamics simulations and energy calculations, Int. J. Quantum Chem. 2022, 122(21), e26980.

21. C. Wang, L. Chen, R.G. Wang, W.X. Tang, B. Zhao, Effects of the G48M mutant on the dynamics properties and binding mechanism of PR with SQV and ATV, Mol. Simulat. 2022, 48(9), 812-824.

22. H. Sun, W. Chen, L. Chen, W.Q. Zheng, Exploring the molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 using molecular dynamics simulation and free energy calculation, J. Comput. Chem. 2022, 42(23), 1670-1680.

科研项目

1. 大麻二酚与抗炎镇痛靶点的识别机制及药效团模型研究，项目负责人，黑龙江省教育厅基本科研业务费，2024.10—2026.10.

2.不同抗衡离子对阴离子表面活性剂界面性质影响的分子模拟研究，项目负责人，黑龙江省教育厅基本科研业务费，2021.01—2023.12.

3. BTB/POZ锌指蛋白Kaiso对甲基化和非甲基化DNA序列识别机制的理论研究，项目负责人，黑龙江省教育厅基本科研业务费，2018.01—2020.12.

4. 甲型流感病毒M2蛋白的质子传导机理及其与药物结合的理论研究，项目负责人，黑龙江省自然科学基金，2014.07—2017.07.

专利

1.陈林, 赵冰, 王瑞歌. 一种有机化合物的制备方法及应用, 发明专利, ZL.202010359623.3, 授权日期: 2022.06.

专著或教材

1. 陈林, 高爽. 物理化学经典理论体系及应用研究, 北京工业大学出版社, 2017.10.